Mathilde LESCAT

email: mathilde.lescat@inserm.fr
Inserm U722

Ecology and evolution of microorganisms

Contact information - Inserm U722
Faculté de Médecine Xavier Bichat
16, rue Henri Huchard -- 75018 Paris (France)

Tel: 33 (0)1 57 27 75 04 -- Fax: 33 (0)1 57 27 73 72
Bureau: 368
Research interest
The aim of my PhD project was to study the implication of virulence and resistance to antibacterial molecules on E. coli fitness. I am first looking for virulence markers by analysing the data of the project Coliscope, which goal is to sequence and compare several E. coli genomes (https://www.genoscope.cns.fr/agc/mage/wwwpkgdb/Login/log.php?pid=11). I will then perform, based on my first analyses, an epidemiological study on a natural population of E. coli coming from human and animal hosts, living in a unique ecosystem in French Guyana, where antibiotic source is completely controlled. Lastly, I will test the fitness of some selected strains in in vitro and in vivo assays. These results will help us to analyse the relationships between the structure of the E. coli population and the virulence and the resistance of the strains.
Education
Degrees
present: Assistant Professor in Bacteriology, Paris 13 University, France
2009: PhD in Microbiology / Infectious diseases
2006: Master of Medical Bacteriology, Paris 5, 6, 7
2005: Pharmacy diploma, option Medical Biology
2001-2005: Residency, Paris area
1996-2001: Pharmacy school, Paris 5
Exhaustive list of publications
(* Indicates the authors who have equally contributed to the work)
LESCAT M., CLERMONT O., WOERTHER P.L., GLODT J., DION S., SKURNIK D., DJOSSOU F., DUPONT C., PERROZ G., PICARD B., CATZEFLIS F., ANDREMONT A., DENAMUR E.
Commensal Escherichia coli strains in Guiana reveal a high genetic diversity with host-dependant population structure.
Environ Microbiol Rep, 2012, DOI: 10.1111/j.1758-2229.2012.00374.x[Epub ahead of print]
RUIMY R., ANGEBAULT C., DJOSSOU F., DUPONT C., EPELBOIN L., JARRAUD S., ARMAND LEFEVRE L., BES M., LIXANDRU B.E., BERTINE M., EL MINIAI A., RENARD M., BETTINGER R.M., LESCAT M., CLERMONT O., PEROZ G., LINA G., TAVAKOL M., VANDENESCH F., VAN BELKUM A., ROUSSET F., ANDREMONT A.
Host genetics as the predominant determinant of persistent nasal Staphylococcus aureus carriage in humans?
J. Infect. Dis., 2010, 202, 924-934
WOERTHER P.L., ANGEBAULT C., LESCAT M., RUPPE E., SKURNIK D., EL MNIAI A., CLERMONT O., JACQUIER H., DA COSTA A., RENARD M., BETTINGER R.M., EPELBOIN L., DUPONT C., GUILLEMOT D., ROUSSET F., ARLET G., DENAMUR E., DJOSSOU F., ANDREMONT A.
Emergence and dissemination of extended spectrum β-lactamase-producing Escherichia coli in the community: lessons from the study of a remote and controlled population.
J. Infect. Dis., 2010, 202, 515-23
TOUCHON T*., HOEDE H.*, TENAILLON O.*, BARBE V., BAERISWYL S., BIDET P., BINGEN E., BONACORSI S., BOUCHIER C., BOUVET O., CALTEAU A., CHIAPELLO H., CLERMONT O., CRUVEILLER S., DANCHIN A., DIARD M., DOSSAT C., EL KAROUI M., FRAPY E., GARRY L., GHIGO J.M., GILLES A.M., JOHNSON J.R., LE BOUGUENEC C., LESCAT M., MANGENOT S., MARTINEZ-JEHANNE V., MATIC I., NASSIF S., OZTAS S., PETIT M.A., PICHON C., ROUY Z., SAINT RUF C., SCHNEIDER D., TOURRET J., VACHERIE B., VALLENET D., MEDIGUE C., ROCHA E., DENAMUR E.
Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths.
PLoS Genet., 2009, 5, e1000344
LESCAT M., HOEDE C., CLERMONT O., GARRY L., DARLU P., TUFFERY P., DENAMUR E., PICARD B.
aes, the gene encoding the esterase B in Escherichia coli, is a powerful phylogenetic marker of the species.
BMC Microbiol., 2009, 9, 273
LESCAT M., CALTEAU A., HOEDE C., BARBE V., TOUCHON M., ROCHA E., TENAILLON O., MEDIGUE C., JOHNSON J.R., DENAMUR E.
A module located at a chromosomal integration hotspot is responsible for the multiple-resistance of a reference strain from Escherichia coli clonal group A.
Antimicrobial. Agents Chemother., 2009, 53, 2283-2288
CLERMONT O., LESCAT M., O'BRIEN C.L., GORDON D.M., TENAILLON O., DENAMUR E.
Evidence for a human specific Escherichia coli clone.
Environ. Microbiol., 2008, 10, 1000-1006
LESCAT M., DUPEYRON C., FAUBERT E., MANGENEY N.
Pulse-field gel electrophoresis typing of methicillin-resistant Staphylococcus aureus strains susceptible to aminoglycosides isolated from 1993 to 2002.
J Hosp Infect., 2004 Jul;57(3):253-7.