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The spread of antibiotic-resistant pathogens is becoming an extremely serious clinical and public health problem worldwide. Acquired resistance to third generation cephalosporins is mainly mediated by extended-spectrum beta-lactamase (ESBLs). Escherichia coli has been recognized as the major source of ESBLs. The objective of my research project is to understand the evolutionary success of the ESBLs in E. coli and especially the CTX-M enzymes emergence, which have become the most prevalent ESBLs worldwide since the 2000s. To reach this objective, I will first analyze the sequences of plasmids carrying CTX-M genes of a collection of ESBL producing E. coli strains. Then, I will test the fitness of these strains in vitro and in vivo.
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| Degrees |
| present: |
PhD in Microbiology/Infectious diseases |
| 2009: |
Master 2 of Microbiology Paris XI University |
| 2004-2008: |
Resident (medical biology), Lille, France |
| 1999-2004: |
Pharmacy School, Nantes university, France |
| Academic positions |
| present: |
Assistant Professor in Bacteriology, Paris VII University, France |
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Exhaustive list of publications (* Indicates the authors who have equally contributed to the work) |
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MAHJOUB-MESSAI F., DOIT C., KOECK JL., BILLARD T., EVRARD B., BIDET P., HUBANS C., RAYMOND J., LEVY C., COHEN R., BINGEN E.
Population snapshot of Streptococcus pneumoniae serotype 19A isolates before and after introduction of seven-valent pneumococcal Vaccination for French children.
J Clin Microbiol., 2009 Mar;47(3):837-40.
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