Olivier TENAILLON
Research Scientist
email: olivier.tenaillon@inserm.fr
Inserm U722

Ecology and evolution of microorganisms

Contact information - Inserm U722
Faculté de Médecine Xavier Bichat
16, rue Henri Huchard -- 75018 Paris (France)

Tel: 33 (0)1 57 27 75 04 -- Fax: 33 (0)1 57 27 73 72
Bureau: 368
Research interest
To study the evolutionnary potential of microorganisms, I have decided to study the various way in which their genome can evolve. I am interested in the way diversity is produced, how mutation rate and recombination rate are variable and can influence bacterial evolution.I am interested in the way genes are acquired and the relative contribution of acquired genes versus house keeping gene in the adaptation to some specific niches. I am interested in the way interactions whithin a genome are building up and what are their consequences on microbial evolution.
In order to progress in the understanding of microbial genome evolution, I use several approaches : population genetics theory and the simulation of evolving populations with computers, molecular evolution : the study of DNA sequences and experimental evolution : the evolution in the lab of viruses and bacteria.
Education
Degrees
1997-2000: PhD student in evolutionary genetics at the University of Paris VI with B. Godelle, I. Matic, M. Radman and F. Taddei
1996-1997: D.E.A. (master degree) in Evolutionary Biology (University of Paris VI)
1993-1996: Ecole Polytechnique (Palaiseau, France)
Academic positions
2003-present: Research position in Inserm E0339 Ecology and Evolution of Microorganisms
Research training (post doctoral)
2001-2002: Postdoc with Lin Chao at the University of California San Diego (California, USA) (year 2001 with Lavoisier fellowship)
Exhaustive list of publications
(* Indicates the authors who have equally contributed to the work)
MAHARJAN R.P., GAFFE J., PLUCAIN J., SCHLIEP M., WANG L., FENG L., TENAILLON O., FERENCI T., SCHNEIDER D.
A case of adaptation through a mutation in a tandem duplication during experimental evolution in Escherichia coli.
BMC Genomics. 2013, 14, 441
JACQUIER H., BIRGY A., LE NAGARD H., MECHULAM Y., SCHMITT E., GLODT J., BERCOT B., PETIT E., POULAIN J., BARNAUD G., GROS P.A., TENAILLON O.
Capturing the mutational landscape of the beta-lactamase TEM-1.
Proc Natl Acad Sci U S A. 2013, 110, 13067-13072
BLEIBTREU A.*, GROS P.A.*, LAOUENAN C., CLERMONT O., LE NAGARD H., PICARD B., TENAILLON O. DENAMUR E.
Fitness, stress resistance and extraintestinal virulence in Escherichia coli.
Infect Immun, 2013, 81, 2733-2742
RODRIGUEZ-VERDUGO A., GAUT B.S., TENAILLON O.
Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress.
BMC Evol Biol, 2013, 13, 50
WIELGOSS S.*, BARRICK J.E.*, TENAILLON O.*, WISER M.J., DITTMAR W.J., CRUVEILLER S., CHANE-WOON-MING B., MEDIGUE C., LENSKI R.E., SCHNEIDER D.
Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load.
Proc Natl Acad Sci U S A. 2013, 110, 222-227
TENAILLON O., RODRÍGUEZ-VERDUGO A., GAUT R., MCDONALD P., BENNETT A.F., LONG A.D*. & GAUT, B.G*.
The molecular diversity of adaptive convergence.
Science., 2012, 335: 457-461.
LE NAGARD H., CHAO L., TENAILLON O.
The emergence of complexity and restricted pleiotropy in adapting networks.
BMC Evol Biol, 2011, 11, 326
WIELGOSS S., BARRICK J.E., TENAILLON O., CRUVEILLER S., CHANE-WOON-MING B., MéDIGUE C., LENSKI R.E., SCHNEIDER D.
Mutation rate inferred from synonymous substitutions in a long-term evolution experiment with Escherichia coli.
Genes, Genomes, Genetics. 2011, 1:183-186
TOURRET J., ALOULOU M., GARRY L., TENAILLON O., DION S., RYFFEL B., MONTEIRO R., DENAMUR E.
The interaction between a non pathogenic and a pathogenic strain synergistically enhances extra-intestinal virulence in Escherichia coli.
Microbiology, 2011, 157, 774-785
BILLARD-POMARES T., TENAILLON O., LE NAGARD H., ROUY Z., CRUVELLIER S., MÉDIGUE C., ARLET G., DENAMUR E., BRANGER C.
Complete nucleotide sequence of plasmid pTN48 encoding the CTX-M-14 extended spectrum β-lactamase from an Escherichia coli O102-ST405 strain.
Antimicrob. Agents Chemother., 2011, 55, 1270-1273
LESPINATS S., GRANDO D., MARÉCHAL E., HAKIMI M.A., TENAILLON O., BASTIEN O.
How Fitch-Margoliash algorithm can benefit from Multi Dimensional Scaling.
Evolutionary Bioinf., 2011, 7, 61-85
LEVERT M., ZAMFIR O., CLERMONT O., BOUVET O., LESPINATS S., HIPEAUX M.C., BRANGER C., PICARD B., SAINT-RUF C., NOREL F., BALLIAU T., ZIVY M., LE NAGARD H., CRUVELLIER S., CHANE-WOON-MING B., NILSSON S., GUDELJ I., PHAN K., FERENCI T., TENAILLON O., DENAMUR E.
Molecular and evolutionary bases of within-patient genotypic and phenotypic diversity in Escherichia coli extraintestinal infections.
PLoS Pathog., 2010, 6, e1001125
MICHEL A., CLERMONT O., DENAMUR E., TENAILLON O.
Bacteriophage PhiX174’s ecological niche and the flexibility of its Escherichia coli lipopolysaccharide receptor.
Appl. Environ. Microbiol., 2010, 76, 7310-7313
DENAMUR E., PICARD B., TENAILLON O.
Population Genetics of Pathogenic Escherichia coli
Bacterial Population Genetics in Infectious Disease (eds D. A. Robinson, D. Falush and E. J. Feil), John Wiley & Sons, Inc., Hoboken, NJ, USA, 2010, doi: 10.1002/9780470600122.ch14.
TENAILLON O., SKURNIK D., PICARD B., DENAMUR E.
The population genetics of commensal Escherichia coli.
Nature Rev. Microbiol., 2010, 8, 207-217
SCHUBERT S., DARLU P., CLERMONT O., WIESER A., MAGISTRO G., HOFFMANN C., WEINERT K., TENAILLON O., MATIC I., DENAMUR E.
Role of intraspecies recombination in the spread of pathogenicity islands within the Escherichia coli species.
PLoS Pathog., 2009, 5, e10000257
TOUCHON T*., HOEDE H.*, TENAILLON O.*, BARBE V., BAERISWYL S., BIDET P., BINGEN E., BONACORSI S., BOUCHIER C., BOUVET O., CALTEAU A., CHIAPELLO H., CLERMONT O., CRUVEILLER S., DANCHIN A., DIARD M., DOSSAT C., EL KAROUI M., FRAPY E., GARRY L., GHIGO J.M., GILLES A.M., JOHNSON J.R., LE BOUGUENEC C., LESCAT M., MANGENOT S., MARTINEZ-JEHANNE V., MATIC I., NASSIF S., OZTAS S., PETIT M.A., PICHON C., ROUY Z., SAINT RUF C., SCHNEIDER D., TOURRET J., VACHERIE B., VALLENET D., MEDIGUE C., ROCHA E., DENAMUR E.
Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths.
PLoS Genet., 2009, 5, e1000344
BIZE S,, KARLSSON E.A. EKEFJARD K., QUAX T.E., PINA M., PREVOST M.C., FORTERRE P., TENAILLON O., BERNANDER R., PRANGISHVILI D.
A unique virus release mechanism in the Archaea.
Proc Natl Acad Sci U S A, 2009, 106, 11306-11311
GROS P.A., TENAILLON O.
Selection for chaperone like mediated genetic robustness at low mutation rate: impact of drift, epistasis and complexity.
Genetics, 2009, 182, 555-564
LESCAT M., CALTEAU A., HOEDE C., BARBE V., TOUCHON M., ROCHA E., TENAILLON O., MEDIGUE C., JOHNSON J.R., DENAMUR E.
A module located at a chromosomal integration hotspot is responsible for the multiple-resistance of a reference strain from Escherichia coli clonal group A.
Antimicrobial. Agents Chemother., 2009, 53, 2283-2288
GROS P.A.*, LE NAGARD H.*, TENAILLON O.
The evolution of epistasis and its links with genetic robustness, complexity and drift in a phenotypic model of adaptation.
Genetics, 2009, 182, 277-293
TENAILLON M.I., AUSTERLITZ F., TENAILLON O.
Apparent mutational hotspots and long distance linkage disequilibrium resulting from a bottleneck.
J. Evol. Biol., 2008, 21, 541-550
MARAIS G.A., CALTEAU A., TENAILLON O.
Mutation rate and genome reduction in endosymbiotic and free-living bacteria.
Genetica, 2008, 134, 205-210
CLERMONT O., LESCAT M., O'BRIEN C.L., GORDON D.M., TENAILLON O., DENAMUR E.
Evidence for a human specific Escherichia coli clone.
Environ. Microbiol., 2008, 10, 1000-1006
LE GALL T.*, CLERMONT O.*, GOURIOU S., PICARD B., NASSIF X., DENAMUR E., TENAILLON O.
Extraintestinal virulence is a coincidental by-product of commensalism in B2 phylogenetic group Escherichia coli strains.
Mol. Biol. Evol., 2007, 24, 2373-2384
NORA T., CHARPENTIER C., TENAILLON O., HOEDE C., CLAVEL F., HANCE A.J.
Contribution of recombination to the evolution of human immunodeficiency viruses expressing resistance to antiretroviral treatment.
J. Virol., 2007, 81, 7620-7628
TENAILLON O.*, SILANDER O.K. *, UZAN J.P., CHAO L.
Quantifying organismal complexity using population genetics approach.
PLoS One., 2007, 2, e217
SILANDER O.K.*, TENAILLON O. *, CHAO L.
Understanding the evolutionary fate of finite populations: the dynamics of mutational effects.
PLoS Biol., 2007, 5, e94
HOEDE C., DENAMUR E., TENAILLON O.
Selection acts on DNA secondary structures to decrease transcriptional mutagenesis.
PLoS Genet., 2006, 2, e176
CHARPENTIER C., NORA T., TENAILLON O., CLAVEL F., HANCE A.J.
Extensive recombination between HIV-1 quasispecies makes an important contribution to viral diversity in individual patients.
J. Virol., 2006, 80, 2472-2482
DENAMUR E., TENAILLON O., DESCHAMPS C., SKURNIK D., RONCO E., GAILLARD J.L., PICARD B., BRANGER C., MATIC I.
Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli.
Genetics., 2005, 171:825-7
MONTVILLE R.*, FROISSART R.*, REMOLD S.K., TENAILLON O., TURNER P.E.
Evolution of mutational robustness in RNA viruses.
PLoS Biol, 2005, 3, e381
DENAMUR E., TENAILLON O., DESCHAMPS C., SKURNIK D., RONCO E., GAILLARD J.L., PICARD B., BRANGER C., MATIC I.
Intermediate mutation rates favor evolution of multidrug resistance
Genetics, 2005, 171, 825-827
TENAILLON O., DENAMUR E., MATIC I.
Evolutionary significance of stress-induced mutagenesis in bacteria.
Trends Microbiol., 2004, 12, 264-270
TENAILLON M.I., U'REN J., TENAILLON O., GAUT B.S.
Selection versus demography: A multilocus investigation of the domestication process in maize.
Mol. Biol. Evol., 2004, 21, 1214-1225
BJEDOV I., LECOINTRE G., TENAILLON O., VAURY C., RADMAN M., TADDEI F., DENAMUR E., MATIC I.
Polymorphism of genes encoding SOS polymerases in natural populations of Escherichia coli.
DNA Repair, 2003, 2, 417-426
BJEDOV I.*, TENAILLON O.*, GERARD B.*, SOUZA V., DENAMUR E., RADMAN M., TADDEI F., MATIC I.
Stress-induced mutagenesis in bacteria.
Science, 2003, 300, 1404-1409
MATIC I., TENAILLON O., LECOINTRE G., DARLU P., RADMAN M., TADDEI F., DENAMUR E.
Horizontal transfer of mismatch repair genes and the variable speed of bacterial evolution.
In Horizontal Gene Transfer 2nd Edition (Syvanen, M., and Kado, C.I. Eds.) Academic Press Inc. London, 2002, 145-154
TENAILLON O., TADDEI F., RADMAN M., MATIC I.
Second order selection in bacterial evolution: selection acting on mutation and recombination rates in the course of adaptation.
Res. Microbiol., 2001, 152, 11-16
PORCHER E., TENAILLON O., GODELLE B.
From metabolism to polymorphism in bacterial populations: a theoretical study.
Evolution, 2001, 55:2181-2193
TENAILLON O., LE NAGARD H., GODELLE B., TADDEI F.
Mutator and sex in bacteria: conflict between adaptive strategies.
Proc. Natl. Acad. Sci. USA, 2000, 97, 10465-1047
DENAMUR E., LECOINTRE G., TADDEI F., DARLU P., TENAILLON O., ACQUAVIVA C., SAYADA C., ELION J., RADMAN M., MATIC I.
Evolutionary implications of the frequent horizontal transfer of mismatch repair genes.
Cell, 2000, 103, 711-721
TENAILLON O., TOUPANCE B., LE NAGARD H., TADDEI F., GODELLE B.
Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria.
Genetics, 1999, 152: 485-493