|
Inserm U722 Ecology and evolution of microorganisms Contact
information - Inserm U722 |
||||||||||||
|
|||||||||||||
To study the evolutionnary potential of microorganisms, I have decided to study the various way in which their genome can evolve. I am interested in the way diversity is produced, how mutation rate and recombination rate are variable and can influence bacterial evolution.I am interested in the way genes are acquired and the relative contribution of acquired genes versus house keeping gene in the adaptation to some specific niches. I am interested in the way interactions whithin a genome are building up and what are their consequences on microbial evolution. In order to progress in the understanding of microbial genome evolution, I use several approaches : population genetics theory and the simulation of evolving populations with computers, molecular evolution : the study of DNA sequences and experimental evolution : the evolution in the lab of viruses and bacteria. |
|||||||||||||
Degrees
Academic positions
Research
training (post doctoral)
|
|||||||||||||
LE GALL T.*, CLERMONT O.*, GOURIOU S., PICARD B., NASSIF X., DENAMUR E., TENAILLON O. Extraintestinal virulence is a coincidental by-product of commensalism in B2 phylogenetic group Escherichia coli strains. Mol. Biol. Evol., 2007, 24, 2373-2384 *The two first authors have equally contributed to the work |
|||||||||||||
SILANDER O.K.*, TENAILLON O. *, CHAO L. Understanding the evolutionary fate of finite populations: the dynamics of mutational effects. PLoS Biol., 2007, 5, e94 * The two first auhors have equally contributed to the work |
|||||||||||||
TENAILLON O.*, SILANDER O.K. *, UZAN J.P., CHAO L. Quantifying organismal complexity using population genetics approach. PLoS One., 2007, 2, e217 * The two first auhors have equally contributed to the work |
|||||||||||||
NORA T., CHARPENTIER C., TENAILLON O., HOEDE C., CLAVEL F., HANCE A.J. Contribution of recombination to the evolution of human immunodeficiency viruses expressing resistance to antiretroviral treatment. J. Virol. 2007, 81, 7620-7628 |
|||||||||||||
CHARPENTIER C., NORA T., TENAILLON O., CLAVEL F., HANCE A.J. Extensive recombination between HIV-1 quasispecies makes an important contribution to viral diversity in individual patients. J. Virol., 2006, 80, 2472-2482 |
|||||||||||||
HOEDE C., DENAMUR E., TENAILLON O. Selection acts on DNA secondary structures to decrease transcriptional mutagenesis. PLoS Genet., PLoS Genet., 2006, 2, e176 |
|||||||||||||
MONTVILLE R.*, FROISSART R.*, REMOLD S.K., TENAILLON O., TURNER P.E. Evolution of mutational robustness in RNA viruses. PLoS Biol, 2005, 3, e381 *The two first authors have equally contributed to the work |
|||||||||||||
TENAILLON
O., DENAMUR ., MATIC I., (2004) Evolutionnary significance of stress induced mutagenesis. Trends in Microbiology, 12:264-270 |
|||||||||||||
TENAILLON
M.I., U'REN J., TENAILLON O. , GAUT B.S. (2004) Selection versus demography: a multilocus investigation of the domestication process in maize. Mol. Biol. Evol. 21:1214-1225 |
|||||||||||||
BJEDOV
I., TENAILLON O., GERARD SOUZA V., DENAMUR E., RADMAN M.,
TADDEI F., and MATIC I. (2003) Stress-Induced Mutagenesis in Bacteria. Science 300:1404-1409 |
|||||||||||||
BJEDOV
I., LECOINTRE G., TENAILLON O., VAURY C., RADMAN M., TADDEI
F., DENAMUR E. and MATIC I. (2003) Polymorphism of genes encoding SOS polymerases in natural populations of Escherichia coli. DNA Repair, 2: 417-426 |
|||||||||||||
PORCHER
E., TENAILLON O., GODELLE B. (2002) From Metabolism to Polymorphism in bacterial populations: a theoretical study. Evolution 55:2181-2193 |
|||||||||||||
GIRAUD A. ,
MATIC I., TENAILLON O., CLARA A., RADMAN M., FONS M., TADDEI
F. (2001) Cost and benefit of high mutation rates: adaptive evolution of bacteria in the mouse gut. Science 191: 2606-2608. |
|||||||||||||
TENAILLON
O., TADDEI F., RADMAN M., MATIC I. (2001) Second order selection in bacteria: Selection acting on mutation and recombination rates in the course of adaptation. Res. Microbiol. 152:11-16. |
|||||||||||||
TENAILLON
O., LE NAGARD H., GODELLE B., Taddei F. (2000) Mutators and sex in bacteria: Conflicts between adaptive strategies. Proc. Natl. Acad. Sci. U.S.A. 97: 10465-10470. |
|||||||||||||
DENAMUR E.,
LECOINTRE G., DARLU P., TENAILLON O., ACQUAVIVA C., SAYADA
C., SUNJEVARIC I., ROTHSTEIN R., ELION J., TADDEI F., RADMAN M. and MATIC
I., appendix by TENAILLON O. (2000) Evolutionary implications of the frequent horizontal transfer of mismatchrepair genes. Cell 103:711-721 |
|||||||||||||
TENAILLON
O., TOUPANCE B., LE NAGARD H., TADDEI F., GODELLE B.(1999) Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria. Genetics 152: 485-493 |