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Tony Le Gall
Graduate Student
email:legall@bichat.inserm.fr

Inserm E0339

Ecology and evolution of microorganisms

Contact information - Inserm E0339
Faculté de Médecine Xavier Bichat
16, rue Henri Huchard -- 75018 Paris (France)

Tel: 33 (0)1 57 27 77 45 -- Fax: 33 (0)1 57 27 77 24
3ème étage - ascenseur B - pièce ??





Research interest
My work is divided in 3 main projects, 2 of which are in collaboration, one with C. Parsot at the INSERM U389 (Pasteur Institute, Paris) and the other one with X. Nassif at the INSERM U570 (Necker Medical School). A common goal of these projects is to measure the extend and the biological meaning of polymorphisms in gene contents and expression patterns in the bacterial model E.coli/Shigella and to correlate these polymorphisms with the ecological and evolutionnary characteristics of the strains. Molecular biology and in silico approaches are used with on one hand macroarrays membranes and on the other hand in silico genomic comparisons.
Education

Degrees

2001-present
 Graduate student in "Sciences de la Vie et de la Santé" - University Bretagne Occidentale realized in the lab' INSERM E0339
2000
 DEA Microbiologie - University Paris 11
1999
 Maîtrise de Biologie Cellulaire et Physiologie - UFR Sciences Brest

 
List of the 10 main publications
ESCOBAR-PARAMO P., LE MENAC'H, LE GALL T., AMORIN C., GOURIOU S., PICARD B., SKURNIK D., DENAMUR E.
Identification of forces shaping the commensal Escherichia coli genetic structure by comparing animal and human isolates.
Environ. Microbiol., 2006, 8, 1975-1984
LE GALL T., DARLU P. ESCOBAR-PARAMO P., PICARD B., DENAMUR E.
Selection-driven transcriptome polymorphism in Escherichia coli/Shigella species. Genome Res., 2005, In press
LE GALL T., MAVRIS M., MARTINO M.C., BERNARDINI M.L., DENAMUR E., PARSOT C.
Analysis of virulence plasmid gene expression defines three classes of effectors in the type III secretion system of Shigella flexneri. Microbiology, 2005, In press
LE GALL T., ESCOBAR- PARAMO P., DARLU P., PICARD B., DENAMUR E.
Phylogenetic Analysis of Transcriptome in Escherichia coli species. Internal seminar U571. Necker Medical School (University Paris 5), february 2002.
LE GALL T., ESCOBAR- PARAMO P., DARLU P., PICARD B., DENAMUR E.
Le transcriptome n'est pas relié à la phylogénie mais à la spécialisation". Journée de la Recherche". Bichat Medical School (University Paris 7), september 2002. 
LE GALL T., SANSONETTI P., DENAMUR E., PARSOT C.
Le transcriptome du plasmide de virulence chez Shigella flexneri sérotype 5 souche M90T : Etude des régulateurs transcriptionnels codés par le plasmide et des conditions régulatrices de la transcription. Internal seminar U389. Pasteur Institute (Paris), june 2003.
LE GALL T., ESCOBAR-PARAMO P., DARLU P., PICARD B., DENAMUR E.
Selection Driven Transcriptome Polymorphism in Escherichia coli / Shigella species. Seminar "Infection Pathogenesis and Evolution". Bichat Medical School (University Paris 7), april 2004. •