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Pierre-Alexis Gros
Ph.D.Student
email : pierre-alexis.gros@inserm.fr


Inserm U722

Ecology and evolution of microorganisms

Contact information - Inserm U722
Faculté de Médecine Xavier Bichat
16, rue Henri Huchard -- 75018 Paris (France)

Tel: 33 (0)1 57 27 75 04 -- Fax: 33 (0)1 57 27 77 24
3ème étage - ascenseur B - pièce 3100







Research interest
At a short time scale the behaviour of an evolving population mainly depends on the selective effect of point mutations. Today only few experimental data are available and nothing is really known about the distribution of deleterious effects. My work is orientated towards the determination of the probability distribution of the fitness modification caused by mutations and the influence of the genetic background (especially commensally or pathogenic strains) or genes specificities such as expression level, essentiality, protein designability, etc. I am using fluorescence and competition experiments to measure fitness of different Escherichia coli strains and mutants. I am also interested in the theoretical consequences on evolution of the shape of this probability function and especially of mutational robustness.
Education

Degrees

2005-2006
 Second year Master "Genetics" at the Paris 7 University, Paris.
2002-2005
 Major in Biology at the Ecole Polytechnique, Paris (Palaiseau).
1999-2002
 Preparatory studies in mathematics, physics and chemistry for the competitive entrance examinations to the French “Grandes Ecoles” at the Lycée Sainte-Geneviève, Versailles.

Professional Experience

2006
 Internship at Hartl laboratory (Harvard University – Cambridge) and Inserm U722 (Paris) (mutational robustness and sign epistasis in the beta-lactam resistance) (6 months)
2005

Internship at Inserm U722 (Chaperon proteins and mutational robustness) (3 months)