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Hervé Jacquier
PhD student
email : herve.jacquier@lrb.aphp.fr


Inserm U722

Ecology and evolution of microorganisms

Contact information - Inserm U722
Faculté de Médecine Xavier Bichat
16, rue Henri Huchard -- 75018 Paris (France)

Tel: 33 (0)1 57 27 77 45 -- Fax: 33 (0)1 57 27 77 24
3ème étage - ascenseur B - pièce 399




Research interest
Despite wide use of antibiotics for several decades, bacteria are still a threat in infectious diseases because of acquisition of different ways of resistance to antibiotics. Therefore, I am interested in the adaptation of bacteria to their environment, especially under antibiotic pressure. Escherichia coli is a commensal gut bacterium of vertebrates, found in the environment and involved in numerous human and animal pathologies. The resistance to penicillins, frequent in E. coli, is often mediated by the enzyme TEM-1. By mutations appearance in TEM-1 E. coli adapted to new generations of b-lactams as 3rd generation cephalosporins. Hence, in the order to understand the adaptive dynamics of E. coli, we use TEM-1 as a model to investigate the distribution of mutations effects on the fitness.
Education

Degrees

Present
 Preparing a PhD in Microbiology/Infectious diseases
2007
 PharmD., option Medical Biology, Paris V University, France
2006
 Master of Fundamental Bacteriology, Paris V University, France
2005
 Diploma of Bacteriology, Pasteur Institute, Paris, France
2002-2007
 Residency, Paris, France
1997-2002
 Faculty of pharmaceutical sciences, Paris V University, France

Academic positions

2007-present
 Assistant Professor in Bacteriology, Paris 7 University, France

Exhaustive list of publications
JACQUIER H., MAZEL D., ZAOUI C., SANSON-LE-PORS MJ., BERCOT B.
Contributions of the attC sites for the expression of the second gene in class 1 integrons. Mol Microbiol.,
in revision
FIHMAN V., LARTIGUE MF., JACQUIER H., MEUNIER F., SCHNEPF N., RASKINE L., RIAHI J., SANSON-LE-PORS MJ., BERCOT B.
Appearance of aac(6')-Ib-cr gene among extended-spectrum beta-lactamase-producing Enterobacteriaceae in a French hospital. J. Infect., 2008, 56 : 454-9
in revision
JACQUIER H., CRUAUD P., POILANE I., LACHASSINNE E., GAUDELUS J., COLLIGNON A.
In vitro activity of moxiflxacin (8-methoxyquinolone) alone or in combination with cefotaxime against group B streptococci. Pathol. Biol. (Paris), 2007, 55 : 412-7