Ecology and Evolution of microorganisms (EMI-E0339)

Erick Denamur
Professor
email: erick.denamur@inserm.fr

Inserm U722

Ecology and evolution of microorganisms

Contact information - Inserm U722
Faculté de Médecine Xavier Bichat
16, rue Henri Huchard -- 75018 Paris (France)

Tel: 33 (0)1 57 27 77 39 -- Fax: 33 (0)1 57 27 77 24
3ème étage - ascenseur B - pièce 393

Research interest

Education

List of the 10 main publications

Exhaustive list of publications

Research interest

My goal is to bring fundamental evolutionary approach in medical research. After an interest in human genetic diseases, especially cystic fibrosis, I now focus on the infectious diseases where I try to understand, in an ecological and evolutionary perspective, how bacteria become pathogenic and eventually resistant. The bulk of my work is based on Escherichia coli, which is a natural inhabitant of the gut flora of vertebrates, including humans, but also frequently involved in a broad spectrum of intestinal (diarrhoea) and extra intestinal (urinary tract infection, septicemia, meningitis) diseases. The used approach is to reconstruct the evolutionary scenario of bacterial adaptation, including virulence and resistance, using numerous natural isolates from various origins.

Education

Degrees

1991	Ph. D. in Biological Chemistry and Molecular Biology, Paris 11 University
1986	M. D. Amiens Medical School, Picardie University

Academic positions

2000-present	Professor in Biochemistry and Molecular Biology, Xavier Bichat Medical School, Paris 7 University
1994-2000	Associate Professor in Genetics, Xavier Bichat Medical School, Paris 7 University
1989-1991	Assistant Professor in Biochemistry and Molecular Biology, Xavier Bichat Medical School, Paris 7 University
1988-1989	Assistant Professor in Bacteriology, Amiens Medical School, Picardie University
1982-1988	Resident, University Hospital of Amiens

Research training (post doctoral)

2003-present	Director of the INSERM unit E0339 "Ecology and evolution of microorganisms", Xavier Bichat Medical School, Paris, then U722 (January 2005)
1994-2002	Head of the team "Cystic fibrosis" then head of the team "Genetic variability and evolution" at the INSERM unit 120 then 458, Robert Debré hospital, Paris
1993-1994	Researcher at the INSERM unit 120, Robert Debré hospital, Paris
1991-1993	Visiting Fellow, Department of Laboratory Medicine, Howard Hughes Medical Institute, University of California, San Francisco (Pr Y.W. Kan)

List of the 10 main publications

TENAILLON O., SKURNIK D., PICARD B., DENAMUR E.
The population genetics of commensal Escherichia coli.
Nature Rev. Microbiol., 2010, 8, 207-217

TOUCHON T*., HOEDE H.*, TENAILLON O.*, BARBE V., BAERISWYL S., BIDET P., BINGEN E., BONACORSI S., BOUCHIER C., BOUVET O., CALTEAU A., CHIAPELLO H., CLERMONT O., CRUVEILLER S., DANCHIN A., DIARD M., DOSSAT C., EL KAROUI M., FRAPY E., GARRY L., GHIGO J.M., GILLES A.M., JOHNSON J.R., LE BOUGUENEC C., LESCAT M., MANGENOT S., MARTINEZ-JEHANNE V., MATIC I., NASSIF S., OZTAS S., PETIT M.A., PICHON C., ROUY Z., SAINT RUF C., SCHNEIDER D., TOURRET J., VACHERIE B., VALLENET D., MEDIGUE C., ROCHA E., DENAMUR E.
Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths.
PLoS Genet., 2009, 5, e1000344
*The three first authors have equally contributed to the work

HOEDE C., DENAMUR E., TENAILLON O.
Selection acts on DNA secondary structures to decrease transcriptional mutagenesis.
Genome Res., 2005, 15, 260-265

LE GALL T., DARLU P. ESCOBAR-PARAMO P., PICARD B., DENAMUR E.
Selection-driven transcriptome polymorphism in Escherichia coli/Shigella species.
Genome Res., 2005, 15, 260-265

BJEDOV I., TENAILLON O., GERARD B., SOUZA V., DENAMUR E., RADMAN M., TADDEI F., MATIC I.
Stress-induced mutagenesis in bacteria. Science, 2003, 300, 1404-1409

DENAMUR E., LECOINTRE G., TADDEI F., DARLU P., TENAILLON O., ACQUAVIVA C., SAYADA C., ELION J., RADMAN M., MATIC I.
Evolutionary implications of the frequent horizontal transfer of mismatch repair genes.
Cell, 2000, 103:711-721

PICARD B., SEVALI GARCIA J., GOURIOU S., DURIEZ P., BRAHIMI N. BINGEN E., ELION J., DENAMUR E.
The link between phylogeny and virulence in Escherichia coli extraintestinal infection.
Infect. Immun., 1999, 67:546-553

LECOINTRE G., RACHDI L., DARLU P., DENAMUR E.
Escherichia coli molecular phylogeny using incongruence length difference test.
Mol. Biol. Evol., 1998, 15:1685-1695

MATIC I., RADMAN M., TADDEI F., PICARD B., DOIT C., BINGEN E., DENAMUR E., ELION J.
Highly variable mutation rates in commensal and pathogenic Escherichia coli.
Science, 1997, 277:1833-1834

VUILLAUMIER S., KALTENBOECK B., LECOINTRE G., LEHN P., DENAMUR E.
Phylogenetic analysis of cystic fibrosis transmembrane conductance regulator gene in mammalian species argues for the development of a rabbit model for cystic fibrosis.
Mol. Biol. Evol., 1997, 14, 372-380

Exhaustive list of publications

SCHUBERT S., NÖRENBERG D., CLERMONT O., MAGISTRO G., WIESER A., ROMANN E., HOFFMANN C., WEINERT K., DENAMUR E.
Prevalence and phylogenetic history of the TcpC virulence determinant in the Escherichia coli species.
Int. J. Med. Microbiol. (In press)

TOURRET J., DIARD M., GARRY L., MATIC I., DENAMUR E.
Effects of single and multiple pathogenicity island deletions of uropathogenic Escherichia coli strain 536 on intrinsic extra-intestinal virulence.
Int. J. Med. Microbiol. (In press)

WOERTHER P.L., ANGEBAULT C., LESCAT M., RUPPÉ E., SKURNIK D., EL MNIAI A., CLERMONT O., JACQUIER H., DA COSTA A., RENARD M., BETTINGER R.M., EPELBOIN L., DUPONT C., GUILLEMOT D., ROUSSET F., ARLET G., DENAMUR E., DJOSSOU F., ANDREMONT A.
Emergence and dissemination of extended spectrum β-lactamase-producing Escherichia coli in the community: lessons from the study of a remote and controlled population.
J. Infect. Dis. (In press)

MIHAILA L., WYPLOSZ B., CLERMONT O., GARRY L., HIPEAUX M.C., VITTECOQ D., DUSSAIX E., DENAMUR E., BRANGER C.
Probable intra-family transmission of a highly virulent CTX-M-3-producing Escherichia coli belonging to the emerging phylogenetic subgroup D₂ O102-ST405 clone.
J. Antimicrob. Chemother., (In press, letter)

TENAILLON O., SKURNIK D., PICARD B., DENAMUR E.
The population genetics of commensal Escherichia coli.
Nature Rev. Microbiol., 2010, 8, 207-217

DENAMUR E., DELEZOIDE A.L., ALBERTI C., BOURILLON A., GUBLER M.C., BOUVIER R., PASCAUD O., ELION J., GRANDCHAMP B., MICHEL-CALEMARD L., MISSY P., ZACCARIA I., LE NAGARD H., GERARD B., LOIRAT C. AND THE SOCIÉTÉ FRANÇAISE DE FOETOPATHOLOGIE.
Genotype–phenotype correlations in fetuses and neonates with autosomal recessive polycystic kidney disease.
Kindney Int., 2010, 77, 350-358

ROUX D., GAUDRY S., DREYFUSS D., EL-BENNA J., DE PROST N., DENAMUR E., SAUMON G., RICARD J.D.
Candida albicans impairs macrophage function and facilitates Pseudomonas aeruginosa pneumonia in rat.
Crit. Care Med., 2009, 37, 1062-1067

DESMARD M., DAVIDGE K., BOUVET O., MORIN D., ROUX D., FORESTI R., RICARD J.D., DENAMUR E., POOPLE R.K., MONTRAVERS P., MOTTERLINI R., BOCZKOWSKI J.
A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia, FASEB J.,2009, 23, 1023-1031

DESCHAMPS C., CLERMONT O., HIPEAUX M.C., ARLET G., DENAMUR E., BRANGER C.
Multiple arrivals of CTX-M-plasmids in the rare D₂ genotype of Escherichia coli argue for convergent evolution.
Microbiology, 2009, 155, 1656-1668

PEIGNE C., BIDET P., MAHJOUB-MESSA F., PLAINVERT C., BARBE V., MEDIGUE C., FRAPY E., NASSIF X., DENAMUR E., BINGEN E., BONACORSI S.
The plasmid of neonatal meningitis Escherichia coli strain S88 (O45:K1:H7) is closely related to avian pathogenic E. coli plasmids and is associated with high level bacteremia in neonatal rat meningitis model.
Infect. Immun., 2009, 77, 2272-2284

LESCAT M., CALTEAU A., HOEDE C., BARBE V., TOUCHON M., ROCHA E., TENAILLON O., MEDIGUE C., JOHNSON J.R., DENAMUR E.
A module located at a chromosomal integration hotspot is responsible for the multiple-resistance of a reference strain from Escherichia coli clonal group A.
Antimicrobial. Agents Chemother., 2009, 53, 2283-2288

CLERMONT O., DHANJI H., UPTON M., GILBREEL T., FOX A., BOYD D., MULVEY M.R., NORDMANN P., RUPPEE., SARTROU J.L., FRANK T., VIMONT S., ARLET G., BRANGER C., WOODFORD N., DENAMUR E.
Rapid detection of the O25b-ST131 clone of Escherichia coli encompassing the CTX-M-15 producing strains.
J. Antimicrob. Chemother., 2009, 64, 274-277

SKURNIK D., LACHEEB S., BERNEDE C., LE MENAC'H A., ELBAZ S., MOHLER J.., DENAMUR E., ANDREMONT A., RUIMY R.
Integrons and antibiotic resistance in phylogenetic group B2 Escherichia coli.
Microb. Drug Resist., 2009, 15, 173-178

LESCAT M., HOEDE C., CLERMONT O., GARRY L., DARLU P., TUFFERY P., DENAMUR E., PICARD B.
aes, the gene encoding the esterase B in Escherichia coli, is a powerful phylogenetic marker of the species.
BMC Microbiol., 2009, 9, 273

SCHUBERT S., DARLU P., CLERMONT O., WIESER A., MAGISTRO G., HOFFMANN C., WEINERT K., TENAILLON O., MATIC I., DENAMUR E.
Role of intraspecies recombination in the spread of pathogenicity islands within the Escherichia coli species .
PLoS Pathog., 2009, 5, e10000257

CLERMONT O., LESCAT M., O'BRIEN C.L., GORDON D.M., TENAILLON O., DENAMUR E.
Evidence for a human specific Escherichia coli clone.
Environ. Microbiol., 2008, 10, 1000-1006

CLERMONT O., LAVOLLAY M., VIMONT S., DESCHAMPS C., FORESTIER C., BRANGER C., DENAMUR E., ARLET G.
The CTX-M-15-producing Escherichia coli diffusing clone belongs to a highly virulent B2 phylogenetic subgroup.
J. Antimicrob. Chemother., 2008, 61, 1024-1028

GORDON D.M., CLERMONT O., TOLLEY H., DENAMUR E.
Assigning Escherichia coli strains to phylogenetic groups: multi-locus sequence typing versus the PCR triplex method.
Environ. Microbiol., 2008, 10, 2484-2496

SKURNIK D., BONNET D., BERNEDE-BAUDUIN C., MICHEL R., GUETTE C., BECKER J.M., BALAIRE C., CHAU F., MOHLER J., JARLIER V., BOUTIN J.P., MOREAU B., GUILLEMOT D., DENAMUR E., ANDREMONT A., RUIMY R.
Characteristics of human intestinal Escherichia coli with changing environments
Environ. Microbiol., 2008, 10, 2132-2137

LE GALL T.*, CLERMONT O.*, GOURIOU S., PICARD B., NASSIF X., DENAMUR E., TENAILLON O.
Extraintestinal virulence is a coincidental by-product of commensalism in B2 phylogenetic group Escherichia coli strains.
Mol. Biol. Evol., 2007, 24, 2373-2384
*The two first authors have equally contributed to the work

METKAR S., AWASTHI S., DENAMUR E., KIM S.M., GANGLOFF S.C., TEICHBERG S., HAZIOT A., SILVER J., GOYERT S.M.
Role of CD14 in responses to clinical isolates of Escherichia coli: effects of K1 capsule expression.
Infect Immun., 2007, 75, 5415-5424

PLAINVERT C., BIDET P., PEIGNE C., BARBE V., MEDIGUE C., DENAMUR E., BINGEN E., BONACORSI S.
A new O-antigen cluster has a key role in the virulence of the Escherichia coli meningitis clone O45:K1:H7.
J. Bacteriol. 2007, 189, 8528-8536

CLERMONT O., JOHNSON J.R., MENARD M., DENAMUR E.
Determination of Escherichia coli O types by allele-specific PCR: application to bloodstream isolates.
Diagn. Microbiol. Infect. Dis., 2007, 57, 129-136

DIARD M., BAERISWYL S., CLERMONT O., GOURIOU S., PICARD B., TADDEI F., DENAMUR E., MATIC I.
Caenorhabditis elegans as a simple model to study phenotypic and genetic virulence determinants of extraintestinal pathogenic Escherichia coli.
Microbes Infect., 2007, 9, 214-223

DENAMUR E., MATIC I.
Evolution of mutation rates in bacteria.
Mol. Microbiol., 2006, 60, 820-827

SKURNIK D., RUIMY R., ANDREMONT A., AMORIN C., ROUQUET P., PICARD B., DENAMUR E.
Effect of human vicinity on antibiotic resistance and integrons in animal commensal Escherichia coli.
J. Antimicrob. Chemoter., 2006, 57, 1215-1219

ESCOBAR-PARAMO P., LE MENAC'H, LE GALL T., AMORIN C., GOURIOU S., PICARD B., SKURNIK D., DENAMUR E.
Identification of forces shaping the commensal Escherichia coli genetic structure by comparing animal and human isolates.
Environ. Microbiol., 2006, 8, 1975-1984

JOHNSON J.R., CLERMONT O., MENARD M., KUSKOWSKI M.A., MENARD M., PICARD B., DENAMUR E.
Experimental mouse lethality of Escherichia coli isolates in relation to accessory raits, physlogenetic group, and clinical source.
J. Infect Dis., 2006, 194, 1141-1150

CATTOIR V., LESPRIT P., LASCOLS C., DENAMUR E., LEGRAND P., SOUSSY CJ., CAMBAU E.
In vivo selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but sensibility to nalidixic acid.
J. Antimicrob. Chemoter., 2006, 58, 1054-1057

SKURNIK D., LE MENAC'H A., ZURAKOWSKI D., MAZEL D., COURVALIN P., DENAMUR E., ANDREMONT A., RUIMY R.
Integron-associated antibiotic resistance and phylogenetic groups in Escherichia coli from healthy subjects free of recent antibiotic exposure. Antimicrob.
Agents Chemoter., 2005, 49, 3062-3065

HOMMAIS F., PEREIRA S., ACQUAVIVA C., ESCOBAR-PARAMO P., DENAMUR E.
Single-nucleotide polymorphism (SNP) phylotyping in Escherichia coli. Appl.
Environ. Microbiol., 2005, 71, 4784-4792

DENAMUR E., TENAILLON O., DESCHAMPS C., SKURNIK D., RONCO E., GAILLARD J.L., PICARD B., BRANGER C., MATIC I.
Intermediate mutation rates favor evolution of multidrug resistance.
Genetics, 2005, 171, 825-827

SUCHLAND R.J., BOURILLON A., DENAMUR E., STAMM W.E., ROTHSTEIN D.M.
Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil. Antimicrob.
Agents Chemoter., 2005, 49, 1130-1126

LABAT F., PRADILLON O., GARRY L., PEUCHMAUR M., FANTIN B., DENAMUR E.
Mutator phenotype confers advantage in Escherichia coli chronic urinary tract infection pathogenesis. FEMS Immunol.
Med. Microbiol., 2005, 44, 317-321

LE GALL T., DARLU P. ESCOBAR-PARAMO P., PICARD B., DENAMUR E.
Selection-driven transcriptome polymorphism in Escherichia coli/Shigella species.
Genome Res., 2005, 15, 260-265

LE GALL T., MAVRIS M., MARTINO M.C., BERNARDINI M.L., DENAMUR E., PARSOT C.
Analysis of virulence plasmid gene expression defines three classes of effectors in the type III secretion system of Shigella flexneri.
Microbiology, 2005, 151, 951-962

TENAILLON O., DENAMUR E., MATIC I.
Evolutionary significance of stress-induced mutagenesis in bacteria.
Trends Microbiol., 2004, 12, 264-270

ESCOBAR-PARAMO P., CLERMONT P., BLANC-POTARD A. B., BUI H., LE BOUGUENEC C., DENAMUR E.
A specific genetic background is required for acquisition and expression of virulence factors in Escherichia coli.
Mol. Biol. Evol., 2004, 21, 1085-1094

ESCOBAR-PARAMO P., SABBAGH A., DARLU P., PRADILLON O., VAURY C., DENAMUR E., LECOINTRE G.
Decreasing the effects of horizontal gene transfer on bacterial phylogeny : the Escherichia coli case study.
Mol. Phyl. Evol. 2004, 30, 243-250

SIMON-BOUY B., SATRE V., FEREC C., MALINGE M.C., GIRODON E., DENAMUR E., LEPORRIER N., LEWIN P., FORESTIER F., MULLER F.
Hyperechogenic fetal bowel: A large French collaborative study of 682 cases.
Am J Med Genet., 2003, 121, 209-213

KESROUANI A.K., GUIBOURDENCHE J., MULLER F., DENAMUR E., VUILLARD E., GARELl C., DELEZOIDE A.L., EYDOUX P., TACHDJAN G., LEBON P., DE LAGAUSIE P., SIBONY O., BAUMAN C., OURY J.F., LUTON D.
Etiology and outcome of fetal echogenic bowel. Ten years of experience.
Fetal Diagn. Ther., 2003, 18, 240-246

BJEDOV I.*, TENAILLON O.*, GERARD B.*, SOUZA V., DENAMUR E., RADMAN M., TADDEI F., MATIC I.
Stress-induced mutagenesis in bacteria.
Science, 2003, 300, 1404-1409
* The there first auhors have equally contributed to the work

LOIRAT C., ANDRE J.L., CHAMPIGNEULLE J., ACQUAVIVA C., CHANTEREAU D., BOURQUARD R., ELION J., DENAMUR E.
WT1 splice site mutation in a 46,XX female with minimal-change nephrotic syndrome and Wilms tumour.
Nephrol. Dial. Transplant., 2003, 18, 826-825

HOMMAIS F., GOURIOU S., AMORIN C., BUI H., RAHIMY M.C., PICARD B., DENAMUR E.
FimH A27V mutation is pathoadaptive for urovirulence in Escherichia coli B2 phylogenetic group isolates. Infect. Immun., 2003, 71, 3619-3622

ESCOBAR-PARAMO P., GIUDICELLI C., PARSOT C., DENAMUR E.
The evolutionary history of Shigella and enteroinvasive Escherichia coli revised. J. Mol. Evol., 2003, 57, 140-148

BJEDOV I., LECOINTRE G., TENAILLON O., VAURY C., RADMAN M., TADDEI F., DENAMUR E., MATIC I.
Polymorphism of genes encoding SOS polymerases in natural populations of Escherichia coli.
DNA Repair, 2003, 2, 417-426

ROCHA E.P.C., PRADILLON O., BUI H., SAYADA C., DENAMUR E.
A new family of highly variable proteins in the Chlamydophila pneumoniae genome.
Nucleic Acids Res., 2002, 30, 4351-4360

SCHUBERT S., PICARD B., GOURIOU S., HEESEMANN J., DENAMUR E.
Yersinia High-Pathogenicity Island (HPI) contributes to virulence in Escherichia coli causing extraintestinal infections.
Infect. Immun., 2002, 70, 5335-5337

SIMON-BOUY B., MULLER F. and The French Collaborative Group including DENAMUR E.
Hyperechogenic fetal bowel and Down syndrome; Results of a French collaborative study based on 680 prospective cases.
Prenat. Diagn. 2002, 22, 189-192

DENAMUR E., BONACORSI S., GIRAUD A., DURIEZ P., HILALI F., AMORIN C., BINGEN E., ANDREMONT A., PICARD B., TADDEI F., MATIC I.
High frequency of mutator strains among human uropathogenic Escherichia coli isolates.
J. Bacteriol., 2002, 184, 605-609

CHEN J.M., CUTLER C., JACQUES C., BÎUF G., DENAMUR E., LECOINTRE G., MERCIER B., CRAMB G., FEREC C.
A combined analysis on the cystic fibrosis transmembrane conductance regulator: implications for structure and disease models.
Mol. Biol. Evol., 2001, 18, 1771-1788

SWIATECKA-URBAN A., MOKRZYCKI M., KASKEL F., DA SILVA F., DENAMUR E.
Novel WT1 mutation (C388Y) in a female child with Denys-Drash syndrome.
Ped. Nephrol., 2001, 16, 627-630

DELOMENIE C., FOUIX S., LONGUEMAUX S., BRAHIMI N., BIZET C., PICARD B., DENAMUR E., DUPRET J.M.
Identification and functionnal characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid.
J. Bacteriol., 2001, 183, 3417-3427

DURIEZ P., CLERMONT O., BONACORSI O., BINGEN E., ELION J., PICARD B., DENAMUR E.
Commensal Escherichia coli isolates are phylogenetically distributed among geographically distinct human populations.
Microbiology, 2001, 147, 1671-1676

PICARD B., DURIEZ P., GOURIOU S., MATIC I., DENAMUR E., TADDEI F.
Mutator natural Escherichia coli isolates have an unusual virulence phenotype.
Infect. Immun., 2001, 69, 9-14

BONTE A., SCHRODER W., DENAMUR E., QUERFELD U.
Absent pubertal development in a child with chronic renal failure: the case of Frasier syndrome.
Nephrol. Dial. Transplant., 2000, 15, 1688-1690

TREDANO M., TRUFFERT P., DENAMUR E., CNEUDE F., CAPRON F., MANOUVRIER S., FELDMANN D., COUDERC R., ELION J., LACAZE-MASMONTEIL T.
Déficit constitutionnel en protéine B du surfactant pulmonaire : présentation clinique, diagnostic histologique et moléculaire.
Arch. Pediatr., 2000, 7, 641-644

DUNN DT., SIMONDS RJ., BULTERYS M., KALISH LA., MOYE J. Jr., de MARIA A., KIND C., RUDIN C., DENAMUR E., KRIVINE A., LOVEDAY C., NEWELL ML.
Interventions to prevent vertical transmission of HIV-1: effect on viral detection rate in early infant samples.
AIDS, 2000, 14, 1421-1428

DENAMUR E., ANDRE JL., NIAUDET P., LOIRAT C.
Absence of correlation between genotype and the severity of diffuse mesangial sclerosis in Denys-Drash syndrome.
Ped. Nephrol., 2000, 14, 439-440

DENAMUR E., BOCQUET N., BAUDOUIN V., DA SILVA F., SARMIENTO R., PEUCHMAUR M., ELION J., GUBLER M. C., FELLOUS M., NIAUDET P., LOIRAT C.
WT1 splice-site mutations are rarely associated with primary steroid-resistant focal and segmental glomerular sclerosis.
Kidney Int., 2000, 57, 1868-1872

AGUILAR-MARTINEZ P., SCHVED J.F., THURET I., MICHEL G., NEONATAO M.G., PELTIER J.Y., GIROT R., PISSARD D., GALACTEROS F., BACHIR D., ROSE C., PICOT M.C., DENAMUR E., ELION J.
Iron overload in thalassaemias and genetic haemochromatosis.
Eur. J. Haematol., 2000, 64, 279280

JOHNSON J.R., KUSKOWSKI M., DENAMUR E., PICARD B., ELION J.
Clonal origin, virulence factors, and virulence.
Infect. Immun., 2000, 68, 424-425 (letter)

CAVE H., POLAK M., DRUNAT S., DENAMUR E., CZERNICHOW P.
Refinement of the 6q chromosomal region implicated in transient neonatal diabetes mellitus.
Diabetes, 2000, 49, 108-113.

DENAMUR E., BOCQUET N., MOUGENOT B., DA SILVA F., MARTINAT L., LOIRAT C, ELION J., BENSMAN A., RONCO P.
Mother-to-child transmitted WT1 splice-site mutation is responsible for distinct glomerular diseases.
J. Am. Soc. Nephrol., 1999, 10, 2219-2223

TOPALOGLU R., DENAMUR E., AKYUZ C., KALE G., HAZARLI V., BAKKALOGLU A.
Wilms' tumour associated late nephropatic syndrome responsive to treatment.
Nephrol. Dial. Transplant., 1999, 14, 954-956

LECOINTRE G., RACHDI L., DARLU P., DENAMUR E.
Escherichia coli molecular phylogeny using incongruence length difference test.
Mol. Biol. Evol., 1998, 15, 1685-1695

DIXMERAS I., LAPOUMEROULIE C., PASCUAL-LE TALLEC L., BENS M., ELION J., VANDEWALLE A., DENAMUR E.
CFTR regions containing duodenum specific DNase I hypersensitive sites drive expression in intestinal crypt cells but not in fibroblasts. Biochem.
Biophys. Res. Commun., 1998, 250, 328-334

ROLLAND K., LAMBERT-ZECHOWSKI N., PICARD B., DENAMUR E.
Shigella and enteroinvasive Escherichia coli strains are derived from distinct ancestral strains of E. coli.
Microbiology, 1998, 144, 2667-2672.

JEANPIERRE C., DENAMUR E., HENRY I., CABANIS M.O., LUCE S., CECILLE A., ELION J., PEUCHMAUR M., LOIRAT C., NIAUDET P., GUBLER M.C., JUNIEN C.
Identification of constitutional WT1 mutations in patients with isolated diffuse mesangial sclerosis (IDMS) and analysis of genotype-phenotype correlations using a computerized mutation database.
Am. J. Hum. Genet., 1998, 62, 824-833

MULLER F., DOMMERGUES M., SIMON-BOUY B., FEREC C., OURY J.F., AUBRY M.C., BESSIS R., VUILLARD E., DENAMUR E., BIENVENU T., SERRE J.L.
Cystic fibrosis screening: a fetus with hyperechogenic bowel may be the index case.
J. Med. Genet., 1998, 35, 657-660

BINGEN E., PICARD B., BRAHIMI N., MATHY S., DESJARDINS P., ELION J., DENAMUR E.
Phylogenetic analysis of Escherichia coli strains causing neonatal meningitis suggests horizontal gene transfer from a predominant pool of highly virulent B2 group strains.
J. Infect. Dis., 1998, 177, 642-650

VERLINGUE C., VUILLAUMIER S., MERCIER B., LE GAC G., ELION J., FEREC C., DENAMUR E.
Absence of mutations within the interspecies conserved regions of the CFTR promoter region in cystic fibrosis and related patients.
J. Med. Genet., 1998, 35, 137-140

BINGEN E., BONACORSI S., BRAHIMI N., DENAMUR E., ELION J.
Virulence patterns of E. coli K1 associated with neonatal meningitis.
J. Clin. Microbiol., 1997, 35, 2981-2982

MATIC I., RADMAN M., TADDEI F., PICARD B., DOIT C., BINGEN E., DENAMUR E., ELION J.
Highly variable mutation rates in commensal and pathogenic Escherichia coli.
Science, 1997, 277:1833-1834

VUILLAUMIER S., DIXMERAS I., MESSAì H., LAPOUMEROULIE C., LALLEMAND D., GEKAS J., CHEHAB F.F., PERRET C., ELION J., DENAMUR E.
Cross-species characterisation of the CFTR promoter region reveals multiple levels of regulation. Biochem.
J., 1997, 327, 651-662

GOUYA L., PASCAUD O., MUNCK A., ELION J., DENAMUR E.
A novel mutation (A141D) in exon 4 of the CFTR gene identified in an Algerian patient.
Hum. Mut., 1997, 10, 86-87

DOIT C., DENAMUR E., PICARD B., GESLIN P., ELION J., BINGEN E.
Mechanisms of the spread of penicillin resistance in Streptococcus pneumoniae strains causing meningitis in children in France.
J. Infect. Dis., 1996, 174, 520-528

BINGEN E., DENAMUR E., BRAHIMI N., ELION J.
Genotyping may provide rapid identification of Escherichia coli K1 organisms that cause neonatal meningitis.
Clin. Infect. Dis., 1996, 22, 152-156

GERARD B., PEPONNET C., BRUNIE G., CAVE H., DENAMUR E., D'AURIOL L., MONTPLAISIR N., SIMON F., ELION J., GRANDCHAMP B.
Fluorometric detection of HIV-1 genome through use of an internal control, inosine-substituted primers, and microtiter plate format.
Clin. Chem., 1996, 42, 696-703

MESSAOUD T., VERLINGUE C., DENAMUR E., PASCAUD O., QUERE I., FATTOUM S., ELION J., FEREC C.
Distribution of CFTR mutations in cystic fibrosis patients of Tunisian origin. Identification of two novel mutations.
Eur. J. Hum. Genet., 1996, 4, 20-24

CUPPENS H., CASSIMAN J.J. and study participants including DENAMUR E.
A quality control study of CFTR mutation screening in 40 different european laboratories.
Eur. J. Hum. Genet. 1995, 3, 235-245

DUNN D.T., BRANDT C.D., KRIVINE A., CASSOL S.A., ROQUES P., BORKOWSKY W., DE ROSSI A., DENAMUR E., EHRNST A., LOVEDAY C., HARRIS J.A., McINTOSH K., COMEAU A.M., RAKUSAN T., NEWELL M.L., PECKHAM C.S.
The sensitivity of HIV-1 DNA polymerase chain reaction in the neonatal period and the relative contributions of intra-uterine and intra-partum transmission.
AIDS, 1995, 9, F1-F11

SAYADA C., VRETOU E., ORFILA J., ELION J., DENAMUR E.
Heterogeneity within the first constant segment of the major outer membrane protein gene in Chlamydia trachomatis serovar D/Da distinguishes 2 lineages.
C. R. Acad. Sci. Paris, Sciences de la vie/Life Sciences, 1995, 318, 943-949.

DENAMUR E., CHEHAB F. F.
Methylation status of CpG sites in the mouse and human CFTR promoters.
DNA Cell Biol.,1995, 14, 811-815

SAYADA C., DENAMUR E., GRANDCHAMP G., ORFILA J., ELION J.
Denaturing gradient gel electrophoresis analysis for the detection of point mutations in the Chlamydia trachomatis major outer-membrane protein gene.
J. Med. Microbiol., 1995, 43, 14-25

SAYADA C., ANDERSEN A.A., STOREY C., MILON A., EB F., HASHIMOTO N., HIRAI K., ELION J., DENAMUR E.
Usefulness of omp1 restriction mapping for avian Chlamydia psittaci isolate differentiation.
Res. Microbiol., 1995, 146, 155-165

DESJARDINS P., PICARD B., KALTENBACK B., ELION J., DENAMUR E.
Sex in Escherichia coli does not disrupt the clonal structure of the population: evidence from RAPD and rrn RFLP data.
J. Mol. Evol., 1995, 41, 440-448

DUFOURCQ R., VUILLAUMIER S., PASCAUD O., GUIDAL C., OURY JF., ELION J., CHEHAB F., DENAMUR E.
Compound heterozygosity for F508 and F508C in the cystic fibrosis transmembrane conductance regulator gene: a cautionary note on the molecular diagnosis of cystic fibrosis.
Prenat. Diagn., 1994, 14, 1176-1177 (letter)

DENAMUR E., CHEHAB F. F.
Analysis of the mouse and rat CFTR promoter regions.
Hum. Mol. Genet., 1994, 3, 1089-1094

VILMER E., QUELVENNEC E., PLOUVIER E., DENAMUR E., ROHRLICH P., ELION J., STERKERS G.
HLA mismatched cord blood transplantation immunological studies.
Blood Cells, 1994, 20, 235-241

PESCATORE P., MARTEAU P., LEMIERE E., XERRI B., DENAMUR E., ELION J., MATUCHANSKY C., RAMBAUD JC.
Mucoviscidose reconnue après l'âge de 25 ans, revue et devenir des cas de la littérature.
Gastroentérol. Clin. Biol., 1994, 18, 195-199

BINGEN E., DENAMUR E., ELION J.
Use of ribotyping in the epidemiological surveillance of nosocomial outbreaks.
Clin. Microbiol. Rev., 1994, 7:311-327

CAVE H., BINGEN E., ELION J., DENAMUR E.
Differentiation of Escherichia coli using randomly amplified polymorphic DNA analysis.
Res. Microbiol., 1994, 145, 141-150

PICARD B., DENAMUR E., BARAKAT A., ELION J., GOULLET P.
Genetic heterogeneity of Pseudomonas aeruginosa clinical isolates revealed by esterase electrophoretic polymorphism and restriction fragment length polymorphism of the ribosomal RNA gene region.
J. Med. Microbiol., 1994, 40, 312-322

CAVE H., MARIANI P., GRANDCHAMP B., ELION J., DENAMUR E.
Reliability of PCR directly from stool samples: usefulness of an internal control.
BioTechniques, 1994, 16, 809-810

SAYADA C., ANDERSEN A.A., RODRIGUEZ P., EB F., MILON A., ELION J., DENAMUR E.
Homogeneity of the major outer membrane protein gene of feline Chlamydia psittaci.
Res. Vet. Sci., 1994, 56, 116-118

DENAMUR E., PICARD B., DECOUX G., DENIS J-B., GOULLET P., ELION J.
The absence of correlation between allozyme and rrn RFLP analysis indicates a high gene flow rate within human clinical Pseudomonas aeruginosa isolates.
FEMS Microbiol. Lett., 1993, 110, 275-280

DENAMUR E., LEVINE M., SIMON F., ROHRLICH P., CAVE H., RAHIMY C., De CREPY A., BOISSINOT C., LARCHEE R., LESCOEUR B., ELION J., BRUN-VESINET F., VILMER E.
Conversion of HIV-1 viral markers during the first months of life in HIV infected children born to seropositive mothers.
AIDS, 1993, 7, 897-899 (letter)

SIMON F., RAHIMY C., KRIVINE A., LEVINE M., PEPIN J.M., LAPIERRE D., DENAMUR E., VERNOUX L., De CREPY A., BLOT P., VILMER E., BRUN-VEZINET F.
Antibody avidity measurement and immune complex dissociation for serological diagnosis of vertically acquired HIV-1 infection.
J. Acq. Immun. Def. Syndr., 1993, 6, 201-207

BINGEN E., BOISSINOT C., DESJARDINS P., CAVE H., BRAHIMI N., LAMBERT-ZECHOVSKY N., DENAMUR E., BLOT P., ELION J.
Arbitrarily primed polymerase chain reaction provides rapid differenciation of Proteus mirabilis isolates from a pediatric hospital.
J. Clin. Microbiol., 1993, 31, 1055-1059

MARIANI-KURDJIAN P., DENAMUR E., MILON A., PICARD B., CAVE H., LAMBERT-ZECHOVSKY N., LOIRAT C., GOULLET P., SANSONETI P.J., ELION J.
Identification of a clone of Escherichia coli O103:H2 as a potential agent of hemolytic-uremic syndrome in France.
J. Clin. Microbiol., 1993, 31, 2, 296-301

BINGEN E., CAVE H., AUJARD Y., LAMBERT-ZECHOVSKY N., DESJARDINS P., ELION J., DENAMUR E.
Molecular analysis of a multiply recurrent Escherichia coli K1 meningitis in an infant.
Clin. Infect. Dis., 1993, 16, 82-85

SAYADA C., DENAMUR E., ELION J.
Complete nucleotide sequence of the major outer membrane protein gene of Chlamydia trachomatis serovar Da.
Gene, 1992, 120, 129-130

PICARD B., DENAMUR E., SOURIAU A., ORFILA J., RODOLAKIS A., GOULLET Ph.
Enzyme electrophoretic polymorphism differentiates invasive from non-invasive Chlamydia psittaci ruminant isolates.
Res. Microbiol., 1992, 143, 525-531

BINGEN E., DENAMUR E., LAMBERT-ZECHOVSKY N., BRAHIMI N., EL LAKANY M., ELION J.
DNA restriction fragment length polymorphism differentiates recurrence from relapse in treatment failures of Streptococcus pyogenes pharyngitis.
J. Med. Microbiol., 1992, 37, 162-164

VILMER E., STERKERS N., RAHIMY C., DENAMUR E., ELION J., BROYARD A., LESCOEUR B., LOCHE M., TIERCY JM., GIROTA G., BLOT P.
HLA-mismatched cord blood transplantation in a patient with advanced leukemia. Transplantation, 1992, 53, 1155-1157

BINGEN E., DENAMUR E., PICARD B., GOULLET Ph., LAMBERT-ZECHOVSKY N., FOUCAUD P., NAVARRO J., ELION J.
Molecular epidemiological analysis of Pseudomonas aeruginosa strains causing failure of antibiotherapy in cystic fibrosis patients.
Eur. J. Clin. Microbiol. Infect. Dis., 1992, 11, 432-437

BINGEN E., DENAMUR E., LAMBERT N., BRAHIMI N., El LAKANY M., ELION J.
Rapid genotyping shows the absence of cross-contamination in Enterobacter cloacae nocosomial infections.
J. Hosp. Infect., 1992, 21, 95-101

BINGEN E., DENAMUR E., PICARD B., GOULLET P., LAMBERT N., BRAHIMI N., MERCIER J.C., BEAUFILS F., ELION J.
Molecular epidemiology unravels the complexity of neonatal Eschericia coli acquisition in twins.
J. Clin. Microbiol., 1992, 30, 1896-1898

BINGEN E., DENAMUR E., LAMBERT-ZECHOVSKY N., AUJARD Y., BRAHIMI N., GESLIN P., ELION J.
Analysis of DNA restriction fragment length polymorphism provides evidence for breast milk transmission in Streptococcus agalactiae late-onset neonatal infection.
J. Infect. Dis., 1992, 165, 569-573

BINGEN E., DENAMUR E., LAMBERT-ZECHOVSKY N., BOISSINOT C., BRAHIMI C., AUJARD Y., BLOT P., ELION J.
Mother-to-infant vertical transmission and cross-colonization of Streptococcus pyogenes confirmed by DNA restriction fragment length polymorphism analysis.
J. Infect. Dis., 1992, 165, 147-150

DENAMUR E., SAYADA C., SOURIAU A., ORFILA J., RODOLAKIS A., ELION J.
Restriction pattern of the major outer membrane protein gene provides evidence for a homogeneous invasive group among Chlamydia psittaci ruminant isolates.
J. Gen. Microbiol., 1991, 137, 2525-2530

SAYADA C., DENAMUR E., ORFILA J., CATALAN F., ELION J.
Rapid genotyping of the Chlamydia trachomatis major outer membrane protein by the polymerase chain reaction.
FEMS Microbiol. Lett., 1991, 83, 73-786

DENAMUR E., PICARD-PASQUIER N., MURA C., PICARD B., ORFILA J., KRISHNAMOORTHY R.
Comparison among molecular epidemiological tools for Branhamella catarrhalis typing.
Res. Microbiol., 1991, 42: 585-589

DENAMUR E., PICARD B, GOULLET Ph., BINGEN E., LAMBERT N., ELION J.
Complexity of Pseudomonas aeruginosa infection in cystic fibrosis: combined results from esterase electrophoresis and rDNA restriction fragment length polymorphism analysis.
Epidem. Infect., 1991, 106, 531-539

BINGEN E., DENAMUR E., LAMBERT-ZECHOVSKY N., ELION J.
Evidence for the genetic unrelatedness of nosocomial vancomycin-resistant Enterococcus faecium strains in a pediatric hospital.
J. Clin. Microbiol., 1991, 29, 1888-1892

BINGEN E.H., DENAMUR E., LAMBERT-ZECHOVSKY N.Y., BOURDOIS A., CEZARD J. P., NAVARRO J.,
ELION J.
DNA restriction fragment length polymorphism differenciates crossed from independent infections in nosocomial Xanthomonas maltophilia bacteremia.
J. Clin. Microbiol., 1991, 29, 1348-1350

PICARD B., GOULLET Ph., DENAMUR E., SUERMONDT G.
Esterase electrophoresis: a molecular tool for studying the epidemiology of Branhamella catarrhalis nosocomial infection.
Epidem. Infect., 1989, 103, 547-554

DENAMUR E., PAUTARD J.C., DUCROIX J.P., MASMOUDI K., EB F., RIOU J.Y., ORFILA J.
Meningococcal disease due to group A Neisseiria meningitidis in contacts of Mecca pilgrims.
Lancet, 1987, II, 1211 (letter)

ROUE R., DEBORD T., DENAMUR E., FERRY M., DORMONT D., BARRE SINOUSSI F., ROUZIOUX C.
Diagnosis of Toxoplasma encephalitis in absence of neurological signs by CT Scanning in patients with AIDS.
Lancet, 1984, II, 1472 (letter)

DENAMUR E., KALOUSTIAN E., VEYSSIER P., PLOUIN P.F.
Polyuria polydipsia syndrome showing a renal infarction.
Clinical Nephrology, 1984, 22, 107-108 (letter).